That would be pretty easy to do, though a bit ugly IMHO. Just shift right click on on the UnitFrame you want to customize and start playing. You may want to back up your current layout first. Find this file: C:\Program Files\World of Warcraft\WTF\Account\<YOUR ACCOUNT>\SavedVariables\Pitbull.lua (C being the hard drive where WoW is installed, <YOUR ACCOUNT> is the name you log into WoW with) and copy it somwhere else. The only issue you would run into is you can't really specify textures by frame, it is a "global" setting.
Sorry, but i can't found anywhere how to setting each group on one way, i am looking to setup the 1 group on bottom left side on the screen with the members from bottom to top, the 2nd group on top left, from top to bottom, the 3rd one right down from bottom to top the 4th right up from top to bottom. Of course the groups on left side of the screen must have the buffs and debuffs from left to right and the ones on right side from right to left.
[2007/08/24 22:31:43-4-x5]: Interface\FrameXML\GameTooltip.lua:142: attempt to perform arithmetic on a nil value:
XLoot-0.9.39822\XLootRowTools.lua:111: in function <Interface\AddOns\XLoot\XLootRowTools.lua:111>