Do you mean a Bartender key binding issue? The only reason I ask is because as I said, before installing any UI mods this macro worked exactly as advertised: shift+1 fired Corruption, Ctrl+1 fired Amplify Curse and CoA.
This worked up until I installed Bongos2 (which I then disabled because I just didn't like how it did what it did) and bartender3 (which I like very much except for the following issue). Since then pressing and un-modified 1 will send my felguard and cast Immolate while he's on his way. Alt will cast Drain Soul, no problem. Ctrl+1 and Shift+1 do not fire their assigned spells, instead I have to hold the mod key and click the action bar button.
Is this a Bartender issue or a WOW UI setting that I'm missing somewhere? I've been through the interface options several times and have yet to find the silver bullet that restores my macro functions.
If it's a Bartender issue, is there a workaround? I've considered scrapping the macro(s) and moving the modded spells to other action bars and use the appropriate key bindings but that seems a kludgey way of doing things.