If you are using weapon enhancing buffs (such as rogue poisons) the buff wrapping does not work correctly. The buffs extend too far to the right of the frame. They do this per weapon buff you have. For example, if you are using two poisons your buffs will extend out too far by two "buff slots".
This creates an issue if you play with target frame right next to player frame, as the player buffs overlap the target buffs by one for every weapon enhancement.