I've a small problem with Pitbull - I use a multi-button mouse (one of those with navigation buttons for forward/back, in addition to the normal buttons which appear on a wheel mouse)
Using Clique I make use of macro's like that all the time. It sounds like you placed a macro on a action bar button and then bound the button to your mouse key? I'll try that tonight and see if I have the same results.
Any update on this? I noticed that agUF has the same problem but sRaidFrames doesn't...