For some reason i cannot interact with player, party members or raid members unit frames while in a instance. By interacting i mean right clicking on a unit frame and set loot type or follow or promote someone. Outside the instance there are no problems at all.
1. Wrong place to post. This should either go in the official PitBull4 thread, or in the HELP! forum. I've moved your thread.
2. When reporting a problem, make sure you actually describe the problem with enough detail that someone not experiencing the same problem can get some idea of what's happening. "I can't interact" doesn't really say what's happening. Does the menu appear or not? Do you get any error messages or not?
3. You should also try some basic troubleshooting steps and report the results. Does the problem still happen when PitBull4 is the only addon enabled? Does it happen if you reset your PitBull4 settings or switch to a new profile?